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PP-43

Mangiferin alleviates calcification of vascular and smooth muscle cells by

reducing endoplasmic reticulum stress

2
1
Shang-En Huang, Ling-Huei Luo, Jwu-Lai Yeh* ,1,3

1 Department of Pharmacology, College of Medicine, Kaohsiung Medical University,
Kaohsiung, 807, Taiwan
2 Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University,
Kaohsiung, 807, Taiwan
3 Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, 807,
Taiwan
* E-mail: jwulai@kmu.edu.tw

Abstract
The amount of evidence has identified elevated endoplasmic reticulum (ER) stress as a
potential contributor to vascular calcification. Disruption of ER redox homeostasis heightens
ER stress, promoting excessive reactive oxygen species (ROS) generation in both the ER and
mitochondria, which subsequently triggers inflammation and mitochondrial dysfunction.
Mangiferin (MGF), a bioactive compound extracted from the mango tree, is a natural
antioxidant with diverse pharmacological properties, including antioxidant, anti-inflammatory,
and cardioprotective effects. Its glucose moiety with multiple hydroxyl groups may enable
MGF to scavenge ROS, acting as a sugar-based antioxidant in various pathological conditions.
In this study, we investigated whether MGF could prevent vascular calcification and smooth
muscle cell phenotypic switching by restoring ER homeostasis.

Keywords: Endoplasmic reticulum stress; Reactive oxygen species; Mangiferin; Vascular
calcification