Page 234 - 2025中醫藥與天然藥物聯合學術研討會-中醫藥與天然藥物的挑戰Ｘ機遇與未來大會手冊

PP-51

Salvia miltiorrhiza rescues developmental delay and extends lifespan in

hyperglycemic flies

2,3
1
,4
Chanikan Sangkhathat, Wei-Yong Lin, Hsin-Ping Liu*

1 Graduate Institute of Chinese Medicine, China Medical University, Taichung, Taiwan
2 Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan
3 Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
4 Graduate Institute of Acupuncture Science, China Medical University, Taichung, Taiwan
* E-mail: hpliu@mail.cmu.edu.tw

Abstract
Hyperglycemia, or high blood sugar levels, was linked to reduced lifespan and a heightened
risk of various age-related diseases. The Drosophila (fruit flies) were fed a high-sucrose diet,
and survival and oxidative stress tests were performed to explore the impact of high sugar intake
on aging processes. Salvia miltiorrhiza, commonly known as Danshen (DS), was a traditional
Chinese herb investigated for its therapeutic potential on longevity and age-related conditions.
The results indicated that a high glucose diet significantly impaired fly development, marked
by delayed eclosion times and a lower number of flies that successfully emerged. In survival
tests, flies on a high-sucrose diet showed a notably shorter lifespan and lower survival rates
when exposed to oxidative stress. In contrast, treatment with DS notably reduced
developmental delays, and increased the number of adult flies that emerged from those exposed
to the high-sucrose diet. In addition, DS treatment alleviated the reduction in lifespan and
enhanced the survival rate under oxidative stress conditions. These findings suggested that DS
had been a promising therapeutic for managing hyperglycemia in this fly model, a crucial factor
in aging and related diseases.

Keywords: Salvia miltiorrhiza; Drosophila; Hyperglycemia