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PC-01

Non-polar constituents from the roots of Polygala arillata

4
2
Duy-Hien Tran, #,1,2,3 Nguyen-Bien-Thuy Bui, 1,2,4 Thanh-Hoa Vo, Chia-Ching Liaw, Chih-
,1
5,6
Hua Chao, Ching-Yeu Chen, Mei-Hsien Lee,* Y u -Chi Lin*
7
,2

1 Ph.D. Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy,
Taipei Medical University, Taipei, Taiwan
2 National Research Institute of Chinese Medicine, Taipei, Taiwan
3 School of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi
Minh, Vietnam
4 University of Health Sciences, Vietnam National University Ho Chi Minh City, Ho Chi
Minh, Vietnam
5 School of Pharmacy, China Medical University, Taichung, Taiwan
6 Chinese Medicine Research and Development Center, China Medical University Hospital,
Taichung, Taiwan
7 Department of Physical Therapy, Tzu-Hui Institute of Technology, Pingtung, Taiwan
* E-mail: yclin@nricm.edu.tw

Abstract
Polygala arillata Buch.-Ham. ex D. Don, a member of the genus Polygala (Polygalaceae),
is distributed across tropical Asian regions, including China, India, Thailand, and Vietnam. In
Vietnamese folk medicine, the roots of this species have traditionally been used for the
treatment of bronchitis, neurasthenia, rheumatoid arthritis, and indigestion. A phytochemical
investigation of the dichloromethane fraction of P. arillata roots led to the isolation of one new
depsidone derivative, designated arillatone A (1), together with five known compounds: 1-
methoxy-2,3-methylenedioxyxanthone (2), 1,3-dihydroxy-2-methoxyxanthone (3),
3,5,6,7,8,3,4-hepta-methoxyflavone (4), syringaresinol (5), and dihydrodehydrodiconiferyl
alcohol (6). The chemical structures of these isolates were elucidated by extensive
spectroscopic analyses, including HRMS and NMR, as well as by comparison with published
data. The absolute configuration of compound 1 was further confirmed by DP4+ probability
analysis. The α-glucosidase inhibitory activity of the isolates was subsequently assessed.

Keywords: Polygala arillata; Depsidone; α-Glucosidase