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CM-11

CGPI, a traditional herbal medicine, inhibits the formation of neutrophil

extracellular traps

3
1,2
Y u -Li Chen, Po-Yi Chou, Tsong-Long Hwang* ,1,2

1 Center for Drug Research and Development, College of Human Ecology, Chang Gung
University of Science and Technology, Taoyuan, 333324, Taiwan
2 Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung
University of Science and Technology, Taoyuan, 333324, Taiwan
3 Graduate Institute of Traditional Chinese Medicine, College of Medicine, Chang Gung
University, Taoyuan, 333323, Taiwan
* E-mail: htl@mail.cgust.edu.tw

Abstract
Neutrophil extracellular traps (NETs) play a critical role in the pathogenesis of autoimmune
and inflammatory diseases. CGPI is a traditional herbal medicine used to treat conditions such
as lung abscesses and psoriasis; however, its effects on NETs are unknown. In this study, we
investigated the effects of CGPI on NETs and its mechanisms of action in human neutrophils.
Our results demonstrated that the ethanol extract of CGPI (CGPI-E) significantly inhibited the
production of both extracellular and intracellular reactive oxygen species (ROS), as well as
NETs formation in PMA-stimulated neutrophils. Furthermore, CGPI-E exhibited potent free
radical scavenging activity. Collectively, these findings indicate that CGPI-E effectively
suppresses ROS-dependent NET formation. This study not only supports the traditional use of
CGPI for inflammatory conditions but also highlights its therapeutic potential for NET-
associated diseases.

Keywords: Inflammation; Neutrophil extracellular traps; Reactive oxygen species; Traditional
herbal medicine