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PC-46

A new polyphenol from the fruits of Indigofera hirsuta

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2
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Long-Quan Chang, Yong-Nian Huang, Chia-Hung Yen, Y u -Chang Chen* ,1,2

1 School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung,
Taiwan
2 Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical
University, Kaohsiung, Taiwan
* E-mail: yuchang@kmu.edu.tw

Abstract
Influenza is an acute respiratory disease caused by influenza virus infection.
Research showed that novel influenza A virus (IAV) variants have started to develop resistance
against current available drugs such as neuraminidase inhibitors and M2-ion channel blockers,
which led to the urgent need for new antiviral agents. About 100 species of Formosan plants
have been screened for their anti-IAV activities, and the methanolic extract of the fruits of
Indigofera hirsuta (Fabaceae) exhibited potent neuraminidase 9 active site blocking ability with
an inhibition of 95.71%. A new polyphenol, (2R,3R)-5-hydroxy-2-(3,4,5-trihydroxyphenyl)-
3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-8-one-3-yl 3,4,5-trihydroxybenzoate, along with six
known flavonoids and four phenolics were isolated from the ethyl acetate layer of the extract.
Among the isolates, luteolin, (‒)-epigallocatechin-3-gallate, (‒)-epicatechin-3-gallate, (‒)-
epigallocatechin 3-O-(3,5-O-dimethyl)-gallate, gallic acid, and methyl gallate have shown anti-
IAV activities according to previous studies.

Keywords: Influenza; Indigofera hirsuta; Polyphenols; Neuraminidase; Antiviral