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PC-59

Staurosides A-M: Undescribed sophoradiol-type glycosides from Staurogyne

concinnula (Hance) Kuntze

1
1
1
1
Hung-Tse Huang, Ying-Min Lai, Li-Jie Zhang, Y u -Chi Lin, Y u -Ching Lee, Keng-
1
Chang Tsai, Yaw-Dong Lang,* Chia-Ching Liaw* ,1,2,3,4
,1

1

1 National Research Institute of Chinese Medicine, MOHW, Taipei 112, Taiwan.
2 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807,
Taiwan
3 Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chiao
Tung University, Taipei 112, Taiwan
4 Department of Biochemical Science and Technology, National Chiayi University, Chiayi,
600, Taiwan
* E-mail: ydlang@nricm.edu.tw (Y.D. Lang); liawcc@nricm.edu.tw (C.C. Liaw)

Abstract
Members of the Acanthaceae family, which comprises more than 208 genera and over 4,000
species, are mainly distributed in tropical and subtropical regions. Within this family, the genus
Staurogyne represents one of the larger genera, encompassing approximately 155 species
worldwide. In Taiwan, only two species, S. concinnula (Hance) Kuntze and S. debilis (T.
Anderson) C.B.Clarke ex Mark, have been recorded. S. concinnula is a small perennial herb,
up to 15 cm tall, with a short central stem, a basal rosette of oblanceolate leaves, and is
commonly found in forested streamside habitats. Ethnopharmacologically, S. concinnula has
been traditionally employed in various Asian countries for the treatment of several ailments,
such as hypertension, liver disease, tonsillitis, neuralgia, urethritis, and stroke. However,
phytochemical investigations of the plant remain relatively limited to the best of our knowledge.
In our previous study, five triterpenoid glycosides and four phenylpropanoid glycosides were
isolated from the n-butanol extract. Herein, in our continuing research for the natural products,
we found that eighteen triterpenoids, including fourteen new sophoradiol-type glycosides
staurosides A-N (1-14) and four known ones (15-18), were isolated from the ethanolic extract
of S. concinnula (Hance) Kuntze. Their chemical structures were elucidated through
comprehensive NMR and high-resolution ESIMS. The absolute configuration of the sugar
moiety from the hydrolysis of the isolates was further determined by LC-MS with comparison
of the reference standards.

Keywords: Staurogyne concinnula; Sophoradiol; Glycoside; Staurosides