Page 62 - 2025中醫藥與天然藥物聯合學術研討會-中醫藥與天然藥物的挑戰Ｘ機遇與未來大會手冊

Integrating Pharmacometabolomics and Traditional Wisdom: Evidence-

Based Approaches from Thai Traditional Medicine

Pravit Akarasereenont* ,1,2,3

1 Siriraj Center of Applied Thai Traditional Medicine (Si-CATTM),
2 Division of Inflammopharmacology, Pharmacology Department, Siriraj Metabolomics and
Phenomic Center (SiMPC),
3 WHO CC for traditional medicine in Thailand Faculty of Medicine Siriraj Hospital, Mahidol
University.
* E-mail: pravit.auk@mahidol.ac.th

Abstract
The presentation explores how Thai traditional medical knowledge can be scientifically
validated and advanced through the integration of pharmacometabolomics and evidence-based

research. Anchored in the holistic principles of Thai Traditional Medicine (TTM), the Siriraj
Center of Applied Thai Traditional Medicine (Si-CATTM) has pioneered translational research
that bridges ancient healing practices with modern scientific methodologies.
Key highlights include the application of multi-omics approaches—particularly

metabolomics—in evaluating the efficacy and safety of traditional herbal formulas such as the
Sahatsatara recipe, renowned for its analgesic and anti-inflammatory properties. Clinical trials
ranging from in vitro studies to phase II interventions are presented, demonstrating measurable
outcomes in pain reduction, improved circulation, and enhanced quality of life.

The session also examines the role of Court-type Thai Traditional Massage (CTTM) in
modulating biochemical pathways related to myofascial pain syndrome (MPS), with untargeted
metabolomics profiling revealing shifts in key metabolites and associated pathways before and
after treatment. These findings support TTM’s role in personalized, integrative healthcare and

contribute to its positioning within the global precision medicine landscape.
Finally, the presentation addresses the future of TTM in the digital era—highlighting how AI,
big data, and personalized medicine frameworks can enhance traditional diagnostic and
therapeutic strategies while preserving cultural wisdom. This integrated approach exemplifies

how traditional systems, when scientifically contextualized, can contribute to global health
innovation and holistic well-being.

40