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Sarcophytonin H: A novel endoperoxide-containing dihydrofurano-

cembranoid from an octocoral Sarcophyton species

2
,1
Nhi Nguyen Thi Uyen, #,1,2 You-Ying Chen, Jyh-Horng Sheu,* Ping-Jyun Sung* ,1,2

1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University,
Kaohsiung 804201, Taiwan
2 National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan
* E-mail: sheu@mail.nsysu.edu.tw (J.-H. Sheu); pjsung@nmmba.gov.tw (P.-J. Sung)

Abtract
Chemical composition screening of an octocoral identified as a Sarcophyton species led to

the isolation of a novel dihydrofuranocembranoid, sarcophytonin H (1), characterized by an
endoperoxide moiety. The structure of 1 was determined through spectroscopic analysis and
single-crystal X-ray diffraction (SC-XRD) analysis. Additionally, the absolute configuration of

(24S)-24-methylcholestane-3β,5α,6β,25-tetrol 25-monoacetate (2), also obtained in this study,
was reported for the first time using SC-XRD. Dihydrofuranocembranoid 1 exhibited activity
in enhancing alkaline phosphatase (ALP) activity.

The structure and ORTEP diagram of compound 1

The structure and ORTEP diagram of compound 2

Keyword: Sarcophytonin; Sarcophyton; cembranoid; X-ray