Page 192 - 2025中醫藥與天然藥物聯合學術研討會-中醫藥與天然藥物的挑戰Ｘ機遇與未來大會手冊

PP-10

MPMCA diminishes osteoclast activity: Implications for osteoporosis

therapy and suppression of osteolytic bone metastases

1,2
1
Le Huynh Hoai Thuong, Yueh-Hsiung Kuo, Chih-Hsin Tang* ,1,3

1 Chinese Medicine Research Center, China Medical University, Taichung, Taiwan
2 Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China
Medical University, Taichung, Taiwan
3 Department of Pharmacology, School of Medicine, China Medical University, Taichung,
Taiwan
* Email: chtang@mail.cmu.edu.tw

Abstract
The activity of osteoclasts is pivotal in the progression of osteoporosis and osteolytic bone
metastases. Presently, pharmaceutical treatments for these disorders predominantly aim to
inhibit osteoclast activity. Nonetheless, both antiresorptive and anabolic drugs exhibit
considerable limitations, including both common and rare adverse effects, which constrain their
prolonged usage, particularly in elderly patients and those with multiple chronic ailments.
During our preliminary research, we discovered a novel molecule, N-(4-methoxyphen) methyl
caffeamide (MPMCA), which is a derivative of caffeic acid. This compound demonstrated a
significant capacity to suppress osteoclastogenesis and promote apoptosis in mature osteoclasts
via the MAPK and NF-κB pathways. Furthermore, MPMCA was observed to diminish cell
migration in lung and breast cancer cell lines while preserving cell viability. MPMCA further
reduced osteoclast development produced by the conditioned medium (CM) from lung and
breast cancer cells. Our research demonstrated that MPMCA decreased the expression of
proteolipid protein 2 (PLP2), an oncogenic component implicated in several advanced
malignancies. In vivo, investigations indicated that MPMCA markedly suppressed osteolytic
bone metastases. These findings indicate the possibility of creating an innovative therapeutic
strategy for addressing osteoporosis and osteolytic bone metastases.

Keywords: MPMCA; Lung cancer; Breast cancer; Osteoclastogenesis; Bone metastasis