Page 49 - 2025中醫藥與天然藥物聯合學術研討會-中醫藥與天然藥物的挑戰Ｘ機遇與未來大會手冊

Bridging traditional Chinese medicine and modern medical science: A

comprehensive analysis of cold-hot properties and their therapeutic

correlations

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Huong-Giang Le, Kuei-Hung Lai*

1 PhD Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei
Medical University, Taipei 110301, Taiwan

* E-mail: kueihunglai@tmu.edu.tw

Abstract
This study substantiates the principles of Traditional Chinese Medicine (TCM) by exploring
the relationship between cold-hot properties of TCM and their therapeutic effects on circulatory
and inflammatory conditions. It is hypothesized that hot-natured TCMs are linked to circulatory
diseases, while cold-natured TCMs are associated with anti-inflammatory treatments. A
comprehensive review was conducted, involving literature mining and structural analysis of

key chemical compounds using the Global Natural Product Social Molecular Networking
(GNPS) and Reaxys database. The study analyzed LC-MS/MS data from 24 TCMs to validate
findings from the literature. The review identified 36 plant-derived terpenes from 95 hot-

natured herbs, focusing on their effects on hypertension, coronary artery disease, stroke, and
heart failure. Additionally, 50 plant-derived flavonoid-O-glycosides from 79 heat-clearing
herbs were summarized for their anti-inflammatory properties. The structure-activity
relationships of these compounds were investigated to establish the correlation between the
metabolite composition of TCM formulations and their therapeutic effects. Molecular

networking profiles were used to systematically analyze the metabolome of 24 TCMs,
confirming the critical roles of terpene metabolites in hot-natured and flavonoid-O-glycosides
in cold-natured herbal medicine. The findings provide robust evidence supporting TCM

principles and demonstrate the crucial link between ancient medicinal traditions and modern
medical science. This study not only validates TCM practices but also promotes a seamless
integration of traditional knowledge with contemporary medical research, offering a foundation
for future analysis of TCM metabolomes.

Keywords: Medicinal natures; TCM; Flavonoid-O-glycosides; Anti-inflammation; Terpenoids;
Cardiovascular diseases

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