Page 80 - 2025中醫藥與天然藥物聯合學術研討會-中醫藥與天然藥物的挑戰Ｘ機遇與未來大會手冊

Small Packages, Big Impact: The Next Wave of Extracellular Vesicle

Research Innovations

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Chi-An Cheng*

1 School of Pharmacy, College of Medicine, National Taiwan University, Taipei, 10050 Taiwan

* E-mail: cacheng123@ntu.edu.tw

Abstract
Extracellular vesicle (EV) research is rapidly advancing from fundamental science to

translational applications in EV-based personalized therapeutics and diagnostics. Yet,
fundamental questions persist regarding EV biology and mechanisms, particularly concerning
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the heterogeneous interactions between EVs and cells. Recognizing the multilayered
heterogeneity of EVs as both a challenge and an opportunity, in my presentation, I will highlight
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two exciting EV technological advancements developed by our multidisciplinary group. These
newly developed technologies address technical gaps in dissecting the molecular contents of
EV subsets, contributing to the evolution of EVs as next-generation liquid biopsies for
diagnostics and providing better quality control for EV-based therapeutics. We believe these

novel approaches could facilitate our understanding of diverse EV biology to advance EV-based
personalized diagnostics and therapeutics.

Keywords: Extracellular vesicle; Protein biomarker; Disgnostics; Therapeutics

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