Page 131 - 2025中醫藥與天然藥物聯合學術研討會-中醫藥與天然藥物的挑戰Ｘ機遇與未來大會手冊

PC-14

Study on the bioactive compounds from Streptomyces albogriseolus, a

symbiotic bacterium of the sponge Lendenfeldia species

2
,1,2
Yun-Ting Zeng, #,1,2 You-Ying Chen, Ping-Jyun Sung*

1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University,
Kaohsiung 804201, Taiwan
2 National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan
* E-mail: pjsung@nmmba.gov.tw

Abstract
A new 1-monoglyceride, (S*)-2′,3′-dihydroxypropyl (Z)-14-methylpentadec-9-enoate (1),
and a known fatty acid, 14-methylpentadecanoic acid (2), were isolated from the Gram-positive
bacterium Streptomyces albogriseolus JM128, which is symbiotic with the sponge identified
as Lendenfeldia species. The structure of compound 2 was determined using single-crystal X-
ray diffraction (SC-XRD) analysis. In contrast, the structure of compound 1 was confirmed
through 2D NMR experiments combined with literature data. Both
metabolites 1 and 2 exhibited inhibitory activity on nitric oxide (NO) release at a concentration
of 10 μM.

(S*)-2′,3′-dihydroxypropyl (Z)-14-methylpentadec-9-enoate (1)

14-methylpentadecanoic acid (2)
ORTEP diagram of 2

Keywords: Streptomyces albogriseolus; Lendenfeldia; Monoglyceride; 14-
Methylpentadecanoic acid; Nitric oxide