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PC-18

The study explores the chemical composition and bioactivity of Uvaria

micrantha, a plant native to Vietnam

1
5,6
Szu-Yin Yu, Hsin-Yi Tang, Yang-Chang Wu, 1,2,3,4 Yuh-Chiang Shen, Chia-Ching
1
6
Liaw, Chia-Hong Yen, Tsong-Long Hwang, 1,7,8,9,10 Yi-Hong Tsai, 11,12 Hao-Chun Hu,*
5
,13
Shyh-Chyun Yang,* ,14,15,16 Fang-Rong Chang* ,1

1 Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical
University, Kaohsiung 80708, Taiwan
2 Chinese Medicine Research and Development Center, China Medical University Hospital,
Taichung 404332, Taiwan.
3 Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical
University, Taichung 404332, Taiwan.
4 Master Program of Pharmaceutical Manufacture, College of Pharmacy, China Medical
University, Taichung 404332, Taiwan
5 National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei,
Taiwan
6 National Taipei University of Nursing and Health Science, Taipei City, 112304, Taiwan
7 Chang Gung University of Science and Technology, Taoyuan, Taiwan
8 Graduate Institute of Natural Products, College of Medicine, Chang Gung University,
Taoyuan, Taiwan
9 Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung
University of Science and Technology, Taoyuan, Taiwan
10 Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung
University of Science and Technology, Taoyuan, Taiwan
11 Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical
University, Kaohsiung 807378, Taiwan
12 Department of Pharmacy and Master Program, College of Pharmacy and Health Care,
Tajen University, Pingtung County 907101, Taiwan
13 Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical
University, Kaohsiung, Taiwan
14 School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung,
Taiwan
15 Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical
University, Kaohsiung, Taiwan
16 Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung,
Taiwan
* E-mail: drjcount@livemail.com (Hao-Chun Hu); scyang@kmu.edu.tw (Shyh-Chyun
Yang); aaronfrc@kmu.edu.tw (Fang-Rong Chang)

Abstract
According to reports, Uvaria (Family Annonaceae) has anti-inflammatory, anti-cancer, and
anti-malaria properties. Among these, Uvaria micrantha is found in Australia and Southeast
Asia. But only one study identified the chemicals extracted from U. micrantha stems and their
possible anti-leukemia and anti-cervical cancer properties. This plant has long been used to
heal stomach issues and back discomfort. Eighteen traditional Vietnamese herbal plants were
gathered from Ho Chi Minh City, Vietnam, for this investigation. In cooperation with the
National Research Institute of Chinese Medicine, Taiwan, the n-hexane, n-butanol, water, and
methanol partition layers of 18 different plants were separated and then tested for their anti-